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生物室级大分子学术报告-Plasmon-Enhanced Optical Biosensors for Point-of-Care Detection of Proteins and DNA

发表日期:2016-07-04 04:34  打印  放大 缩小  【关闭

  报告人:Nianqiang Wu,Professor,Department of Mechanical & Aerospace Engineering,West Virginia University

  主持人:朱平研究员

  报告时间:2016年7月5日10:00

  报告地点:9408会议室

  报告人简介:

  Dr. Nianqiang (Nick) Wu is currently Professor of Materials Science in Department of Mechanical & Aerospace Engineering at West Virginia University (WVU), USA. He received his Ph.D. degree in Materials Science & Engineering from Zhejiang University, China in 1997. He was a Postdoctoral Research Fellow at University of Pittsburgh from 1999 to 2001. Afterwards he directed Keck Surface Science Center at Northwestern University in USA in 2001-2005. He then joined WVU as Assistant Professor in 2005, promoted to Associate Professor in 2010 and Full Professor in 2014.

  He currently serves on the advisory board of “Interface”, the home journal of the Electrochemical Society (ECS). He also serves as Vice Chair of Sensor Division in ECS. He has received the Benedum Distinguished Scholar Award, and the Alice Hamilton Award for Excellence in Occupational Safety & Health: Biological Category. He has won the WVU Statler College Outstanding Researcher Award twice.

  Dr. Wu’s current research interest lies in chemical sensors and biosensors for health care and environment monitoring, photocatalysts and photoelectrochemical cells for solar energy harvesting. His research is funded by NSF, NIH and DOE. He has published 1 book entitled “Biosensors Based on Nanomaterials and Nanodevices”, 3 book chapters, 147 peer-reviewed papers in journals such as Nature Photonics, Nature Comm., Journal of the American Chemical Society, Analytical Chemistry and etc.. 20 of his papers are ranked among the top 1% most cited in their subject fields (Thomson Reuters 2015). His papers were cited about 2200 times in a single year 2015 with a total citation count of >10000 times.

  报告摘要:

  This presentation will first introduce the concept of surface plasmon resonance (SPR) and then demonstrate the tuning of SPR by tailoring the particle size, shape and surface chemistry of nanoparticles. Based on the SPR principle, the pH and mercury sensors are developed using the Au nanoparticles. The speech will discuss the nanoscale energy transfer between semiconducting quantum dots (QDs) and gold nanoparticles, and examine the influence of SPR on the fluorescence emission of quantum dots. Following the research results, an ultra-sensitive mercury biosensor is then demonstrated with a QD-DNA-Au ensemble via nano-metal surface energy transfer. In addition, the talk will deal with the effects of SPR on the surface-enhanced Raman scattering (SERS) in the Au@Raman reporter@silica sandwich nanoparticles. Coupling of the core-shell nanoparticles with nano-array chips can enhance the SERS detection of adenosine triphosphate (ATP), DNA, environmental toxins and cancer protein biomarkers. The presentation will also show the effort to integrate nanosensors with a microfluidic chips to form lab-on-chip devices as point-of-care devices for medical diagnosis and environmental monitoring.
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